Halogen Bond and MOFs

New Building Blocks for Chiral Metal-Organic Frameworks (MOFs)

New methodologies are developed for the synthesis of polyhalogenated atropisomeric 4,4’-bipyridines and their functionalization is studied 1, 2, 3, 4. The atropisomeric chiral ligands are used in the preparation of new chiral MOFs 5. Applications in heterogeneous asymmetric catalysis and in chromatography on chiral support are targeted.

Stereoselectivity through Halogen Bond (XB)

In tight collaboration with the Institute of Biomolecular Chemistry ICB-CNR (Italy), we have described that stereoselective XBs are able to control enantioseparation of polyhalogenated atropisomeric 4,4’-bipyridines by HPLC on cellulose-based chiral stationary phases (CSPs) 6, 7, 8. Other chiral halogenated analytes are currently designed and tested for identification of weak stereoselective halogen bond in solution through this analytical technique. New chiral halogenated XB donors for application in asymmetric organocatalysis are targeted. The identification of new chiral chalcogen bond donors by applying the HPLC methodology is currently under investigation.

Collaborations

Dr. Paola Peluso, Institute of Biomolecular Chemistry – C.N.R., UOS of Sassari, Italy.

Dr. Emmanuel Aubert, Laboratoire CRM2, UMR CNRS 7036, Université de Lorraine, Nancy, France.

Prof. Sergio Cossu, Department of Molecular Sciences and Nanosystems, University of Venice, Italy.